Dexamethasone Studies from GEN3VA

The following data was collected from the dexamethasone report on the GEN3VA site, which can be accessed at https://maayanlab.cloud/gen3va/.

Citation for GEN3VA: Gundersen GW, Jagodnik KM, Woodland H, Fernandez NF, Sani K, Dohlman AB, Ung PM, Monteiro CD, Schlessinger A, Ma'ayan A. GEN3VA: aggregation and analysis of gene expression signatures from related studies. BMC Bioinformatics. 2016 Nov 15;17(1):461. doi: 10.1186/s12859-016-1321-1. PMID: 27846806; PMCID: PMC5111283.

Study Title GEO ID Organism GEN3VA Gene Signatures
Alveoli septation inhibition and protection GSE484 Mouse Signature
Antenatal steroid effect on the placenta GSE4165 Mouse Signature
CD4/CD8 double positive thymocyte response to glucocorticoid GSE5463 Mouse Signature
Characterization of Glucocorticoid Receptor (GR) in Mouse Liver GSE75682 Mouse Signature
Cigarette smoke effect on tracheal explants GSE15563 Rat Signature 1 Signature 2
Comparative analysis of gene expression profiles in lymphoma cells after treatment by Dexamethasone or CpdA GSE71102 Human Signature 1 Signature 2
Dexamethasone effect on cultured airway smooth muscle cells - time course GSE34313 Human Signature 1 Signature 2
Dexamethasone effect on fetal chondrocytes in vitro - time course GSE7683 Mouse Signature 1 Signature 2
Dexamethasone effect on glucocorticoid-resistant and -sensitive lymphoblastic leukemia cell lines GSE22152 Human Signature 1 Signature 2
Dexamethasone regulation of mRNAs in astrocytes in vitro GSE39272 Mouse Signature 1 Signature 2 Signature 3 Signature 4 Signature 5 Signature 6 Signature 7 Signature 8
Distinct genome-wide, gene-specific selectivity patterns of four glucocorticoid receptor coregulators GSE58715 Human Signature
Drug Matrix Data - Affymetrix Arrays GSE57822 Rat Signature 1 Signature 2
Ectopic microRNA-150 transcription mimics GR therapy response in GC sensitive MM1S multiple myeloma cells but fails to overcome GC resistance in MM1R cells GSE59805 Human Signature 1 Signature 2 Signature 3 Signature 4
Effect of chronic glucocorticoid (GC) treatment on neonatal mouse whole cerebellum and whole lung GSE51213 Mouse Signature 1 Signature 2
Effects of dexamethasone on cultured lung explant GSE56831 Mouse Signature
Exposure of rat to a variety of toxicants, heart assayed by Affymetrix microarray GSE57800 Rat Signature
Exposure of rat to a variety of toxicants, kidney assayed by Affymetrix microarray GSE57811 Rat Signature 1 Signature 2
Exposure of rat to a variety of toxicants, liver assayed by Affymetrix microarray GSE57815 Rat Signature 1 Signature 2
Expression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages GSE61879 Mouse Signature 1 Signature 2 Signature 3 Signature 4 Signature 5
Expression data from dexamethasone treated mouse embryonic neural progenitor/stem cells isolated from wild type C57Bl/6 or caveolin-1 knockout mice GSE49804 Mouse Signature 1 Signature 2
Expression data from glucocorticoid-treated acute lymphoblastic leukemia cell line, RS4;11 GSE71615 Human Signature 1 Signature 2
Expression data from short-term mouse embryonic stem cell exposure Assay GSE57639 Mouse Signature
Expression of DND41 cell lines treated with 1µM Dexamethasone for 24h after shPTEN infection GSE41062 Human Signature 1 Signature 2 Signature 3
Gene expressions regulated by N/C interacting and non-interactiong GR GSE77752 Human Signature 1 Signature 2
Genome-wide analysis of dexamethasone treated substrates in HeLa cell GSE49591 Human Signature
Glucocorticoid Receptor Confers Resistance to Anti-Androgens by Bypassing Androgen Receptor Blockade GSE52169 Human Signature 1 Signature 2
Glucocorticoid-induced reversal of IL1b stumulated gene expression in OE-E6/7 cells GSE54608 Human Signature
GR and ER co-activation alters the expression of differentiation genes and associates with improved ER+ breast cancer outcome GSE79761 Human Signature
Hes1 and Liver Glucocorticoid Signaling GSE52106 Mouse Signature 1 Signature 2
Hydrogen peroxide-inducible clone-5 deficiency effect on dexamethasone-treated osteosarcoma cells - time course GSE46448 Human Signature 1 Signature 2 Signature 3
In vitro exposure of rat hepatocytes to a variety of toxicants, assayed by Affymetrix microarray GSE57805 Rat Signature 1 Signature 2
In vivo glucocorticoid effect on non-leukemic peripheral blood lymphocytes GSE22779 Human Signature 1 Signature 2 Signature 3
KLF15- and glucocorticoid-dependent transcriptional responses in mouse muscle GSE74624 Mouse Signature 1 Signature 2
Lung response to chronic and acute exposure to ingested arsenic GSE11056 Mouse Signature
Microarray Study Reveals Hormone-Modulated Gene Transcription During Human Podocyte Differentiation GSE39823 Human Signature
Myeloid cells or lung fibroblasts treated with IL-4 or IL-13 GSE47538 Human Signature
Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms - time course GSE6711 Human Signature 1 Signature 2 Signature 3 Signature 4 Signature 5 Signature 6 Signature 7 Signature 8 Signature 9 Signature 10 Signature 11 Signature 12 Signature 13 Signature 14 Signature 15
SUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor (HEK293) GSE48328 Human Signature 1 Signature 2
SUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor (U2Os cell line) GSE48330 Human Signature 1 Signature 2
Transcriptional responses of mouse adipocytes during insulin resistance GSE62635 Mouse Signature 1 Signature 2 Signature 3