Omics Mining for the Illuminating the Druggable Genome Project
Top 200 predicted GO terms, highlighted terms were already annotated.
| GO term | Z-score | DNA replication checkpoint (GO:0000076) | 2.332591402 |
|---|---|
| microtubule depolymerization (GO:0007019) | 2.21478152 |
| DNA strand elongation (GO:0022616) | 2.000595788 |
| DNA strand elongation involved in DNA replication (GO:0006271) | 1.988216225 |
| DNA unwinding involved in DNA replication (GO:0006268) | 1.983020897 |
| protein localization to kinetochore (GO:0034501) | 1.977367252 |
| mitotic sister chromatid segregation (GO:0000070) | 1.958510046 |
| DNA replication-dependent nucleosome assembly (GO:0006335) | 1.948261415 |
| DNA replication-dependent nucleosome organization (GO:0034723) | 1.948261415 |
| regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 1.941180951 |
| chromatin remodeling at centromere (GO:0031055) | 1.923498823 |
| telomere maintenance via semi-conservative replication (GO:0032201) | 1.922900442 |
| DNA replication initiation (GO:0006270) | 1.92218461 |
| protein localization to chromosome, centromeric region (GO:0071459) | 1.917866623 |
| heterochromatin organization (GO:0070828) | 1.903255678 |
| sister chromatid segregation (GO:0000819) | 1.883943905 |
| CENP-A containing nucleosome assembly (GO:0034080) | 1.882074372 |
| synapsis (GO:0007129) | 1.874223217 |
| histone exchange (GO:0043486) | 1.83396706 |
| chromosome condensation (GO:0030261) | 1.826252607 |
| DNA replication-independent nucleosome organization (GO:0034724) | 1.800693033 |
| DNA replication-independent nucleosome assembly (GO:0006336) | 1.800693033 |
| kinetochore organization (GO:0051383) | 1.799019991 |
| kinetochore assembly (GO:0051382) | 1.780131385 |
| mitotic chromosome condensation (GO:0007076) | 1.75925455 |
| microtubule polymerization or depolymerization (GO:0031109) | 1.758945619 |
| mitotic recombination (GO:0006312) | 1.748341311 |
| chromatin assembly or disassembly (GO:0006333) | 1.73891839 |
| mitotic metaphase plate congression (GO:0007080) | 1.735820145 |
| telomere maintenance via recombination (GO:0000722) | 1.728361562 |
| protein localization to chromosome (GO:0034502) | 1.726388298 |
| L-serine metabolic process (GO:0006563) | 1.706964215 |
| meiotic chromosome segregation (GO:0045132) | 1.698210569 |
| DNA strand renaturation (GO:0000733) | 1.697325352 |
| nucleosome assembly (GO:0006334) | 1.684986241 |
| telomere maintenance via telomere lengthening (GO:0010833) | 1.670435672 |
| protein K6-linked ubiquitination (GO:0085020) | 1.650403708 |
| DNA packaging (GO:0006323) | 1.644670287 |
| metaphase plate congression (GO:0051310) | 1.635982235 |
| regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 1.634905127 |
| chromosome organization involved in meiosis (GO:0070192) | 1.633071814 |
| nucleotide-excision repair, DNA gap filling (GO:0006297) | 1.631096805 |
| deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 1.62967786 |
| chromosome segregation (GO:0007059) | 1.62936025 |
| protein-DNA complex assembly (GO:0065004) | 1.624252488 |
| ATP-dependent chromatin remodeling (GO:0043044) | 1.617913288 |
| DNA damage response, detection of DNA damage (GO:0042769) | 1.613006401 |
| regulation of double-strand break repair via homologous recombination (GO:0010569) | 1.608668405 |
| ventricular cardiac muscle cell development (GO:0055015) | 1.607856757 |
| chromatin assembly (GO:0031497) | 1.604404305 |
| resolution of meiotic recombination intermediates (GO:0000712) | 1.597480028 |
| somatic hypermutation of immunoglobulin genes (GO:0016446) | 1.59567765 |
| somatic diversification of immune receptors via somatic mutation (GO:0002566) | 1.59567765 |
| pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 1.595349747 |
| establishment of chromosome localization (GO:0051303) | 1.592469158 |
| maturation of SSU-rRNA (GO:0030490) | 1.584418501 |
| pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 1.57918593 |
| nucleosome organization (GO:0034728) | 1.576021066 |
| regulation of centrosome cycle (GO:0046605) | 1.574484916 |
| pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 1.569616185 |
| DNA topological change (GO:0006265) | 1.564625958 |
| serine family amino acid biosynthetic process (GO:0009070) | 1.557336649 |
| DNA replication (GO:0006260) | 1.55563521 |
| regulation of chromosome segregation (GO:0051983) | 1.552314983 |
| pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 1.547758477 |
| spindle checkpoint (GO:0031577) | 1.546120707 |
| protein-DNA complex subunit organization (GO:0071824) | 1.54100254 |
| base-excision repair (GO:0006284) | 1.533107956 |
| negative regulation of chromosome segregation (GO:0051985) | 1.529324812 |
| regulation of nuclear cell cycle DNA replication (GO:0033262) | 1.524805817 |
| negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 1.523925866 |
| primitive streak formation (GO:0090009) | 1.521565907 |
| * mitotic cell cycle (GO:0000278) | 1.519469816 |
| chaperone-mediated protein transport (GO:0072321) | 1.514346985 |
| maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 1.513880704 |
| DNA ligation (GO:0006266) | 1.511387893 |
| translesion synthesis (GO:0019985) | 1.507847223 |
| chromosome organization (GO:0051276) | 1.504533339 |
| negative regulation of mitotic sister chromatid segregation (GO:0033048) | 1.494427179 |
| negative regulation of sister chromatid segregation (GO:0033046) | 1.494427179 |
| negative regulation of mitotic sister chromatid separation (GO:2000816) | 1.494427179 |
| negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 1.494427179 |
| regulation of G2/M transition of mitotic cell cycle (GO:0010389) | 1.48227682 |
| spindle assembly checkpoint (GO:0071173) | 1.481049408 |
| attachment of spindle microtubules to kinetochore (GO:0008608) | 1.479919108 |
| positive regulation of chromosome segregation (GO:0051984) | 1.473250677 |
| mitotic spindle checkpoint (GO:0071174) | 1.472614639 |
| regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 1.472495156 |
| regulation of spindle organization (GO:0090224) | 1.472219491 |
| negative regulation of gene silencing (GO:0060969) | 1.471800557 |
| * G1/S transition of mitotic cell cycle (GO:0000082) | 1.470518317 |
| * cell cycle G1/S phase transition (GO:0044843) | 1.470518317 |
| negative regulation of cell cycle G2/M phase transition (GO:1902750) | 1.470398447 |
| replication fork processing (GO:0031297) | 1.47006452 |
| negative regulation of G2/M transition of mitotic cell cycle (GO:0010972) | 1.467633791 |
| mitotic spindle assembly checkpoint (GO:0007094) | 1.465264055 |
| deoxyribonucleotide biosynthetic process (GO:0009263) | 1.464578006 |
| protein complex localization (GO:0031503) | 1.464081434 |
| establishment of protein localization to mitochondrial membrane (GO:0090151) | 1.459385021 |
| centriole assembly (GO:0098534) | 1.457573554 |
| regulation of mitotic metaphase/anaphase transition (GO:0030071) | 1.450020515 |
| spliceosomal snRNP assembly (GO:0000387) | 1.449531916 |
| negative regulation of mitosis (GO:0045839) | 1.447771353 |
| nucleobase biosynthetic process (GO:0046112) | 1.442731674 |
| regulation of cell cycle G2/M phase transition (GO:1902749) | 1.440609949 |
| regulation of centriole replication (GO:0046599) | 1.438745262 |
| mitotic nuclear envelope disassembly (GO:0007077) | 1.436589807 |
| DNA damage response, signal transduction resulting in transcription (GO:0042772) | 1.435921764 |
| pyrimidine nucleotide catabolic process (GO:0006244) | 1.435884943 |
| negative regulation of cell division (GO:0051782) | 1.43421703 |
| urogenital system development (GO:0001655) | 1.433573107 |
| ribosomal small subunit biogenesis (GO:0042274) | 1.432451772 |
| regulation of exit from mitosis (GO:0007096) | 1.432341291 |
| * mitotic nuclear division (GO:0007067) | 1.431019129 |
| DNA catabolic process, exonucleolytic (GO:0000738) | 1.430939703 |
| regulation of mitotic sister chromatid segregation (GO:0033047) | 1.428934086 |
| regulation of sister chromatid segregation (GO:0033045) | 1.428934086 |
| regulation of mitotic sister chromatid separation (GO:0010965) | 1.428934086 |
| meiotic cell cycle process (GO:1903046) | 1.427267699 |
| DNA conformation change (GO:0071103) | 1.425357155 |
| positive regulation of cytokinesis (GO:0032467) | 1.420461117 |
| mitotic G2/M transition checkpoint (GO:0044818) | 1.419713095 |
| transcription-coupled nucleotide-excision repair (GO:0006283) | 1.419198752 |
| mitotic spindle organization (GO:0007052) | 1.41745645 |
| * nuclear division (GO:0000280) | 1.414765494 |
| purine nucleobase biosynthetic process (GO:0009113) | 1.413021436 |
| IMP biosynthetic process (GO:0006188) | 1.402232415 |
| spindle organization (GO:0007051) | 1.399472604 |
| pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 1.397511519 |
| meiosis I (GO:0007127) | 1.394756729 |
| negative regulation of nuclear division (GO:0051784) | 1.394210457 |
| telomere organization (GO:0032200) | 1.394038025 |
| anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031145) | 1.392751949 |
| spindle assembly involved in mitosis (GO:0090307) | 1.390149147 |
| ribosomal small subunit assembly (GO:0000028) | 1.389749256 |
| establishment of integrated proviral latency (GO:0075713) | 1.388319231 |
| negative regulation of telomerase activity (GO:0051974) | 1.388219291 |
| mismatch repair (GO:0006298) | 1.38719229 |
| telomere maintenance (GO:0000723) | 1.384211534 |
| negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 1.383165802 |
| regulation of DNA-dependent DNA replication (GO:0090329) | 1.379262937 |
| nuclear envelope disassembly (GO:0051081) | 1.376992239 |
| membrane disassembly (GO:0030397) | 1.376992239 |
| * cell cycle phase transition (GO:0044770) | 1.374240439 |
| * mitotic cell cycle phase transition (GO:0044772) | 1.374086314 |
| regulation of histone H3-K9 methylation (GO:0051570) | 1.37020355 |
| cell cycle checkpoint (GO:0000075) | 1.368377599 |
| DNA recombination (GO:0006310) | 1.366258296 |
| postreplication repair (GO:0006301) | 1.366124938 |
| histone arginine methylation (GO:0034969) | 1.363334132 |
| regulation of mitotic spindle organization (GO:0060236) | 1.362589699 |
| DNA duplex unwinding (GO:0032508) | 1.362367439 |
| protein-DNA complex disassembly (GO:0032986) | 1.357321636 |
| nucleosome disassembly (GO:0006337) | 1.357321636 |
| * organelle fission (GO:0048285) | 1.357298335 |
| CTP metabolic process (GO:0046036) | 1.351114452 |
| CTP biosynthetic process (GO:0006241) | 1.351114452 |
| establishment of mitotic spindle localization (GO:0040001) | 1.34830729 |
| * regulation of mitosis (GO:0007088) | 1.347323772 |
| positive regulation of DNA-dependent DNA replication (GO:2000105) | 1.346648105 |
| DNA integrity checkpoint (GO:0031570) | 1.345600195 |
| mitotic DNA integrity checkpoint (GO:0044774) | 1.345272069 |
| DNA geometric change (GO:0032392) | 1.345230339 |
| regulation of double-strand break repair (GO:2000779) | 1.342727882 |
| ribonucleoprotein complex biogenesis (GO:0022613) | 1.340217043 |
| nucleobase-containing small molecule interconversion (GO:0015949) | 1.33870941 |
| male meiosis I (GO:0007141) | 1.336444581 |
| pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 1.331925357 |
| regulation of centrosome duplication (GO:0010824) | 1.330514478 |
| protein complex disassembly (GO:0043241) | 1.329051236 |
| regulation of mammary gland epithelial cell proliferation (GO:0033599) | 1.327725199 |
| rRNA processing (GO:0006364) | 1.32707159 |
| DNA biosynthetic process (GO:0071897) | 1.322410535 |
| mitotic cell cycle checkpoint (GO:0007093) | 1.321075386 |
| DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978) | 1.320198272 |
| positive regulation of G2/M transition of mitotic cell cycle (GO:0010971) | 1.318953934 |
| positive regulation of cell cycle G2/M phase transition (GO:1902751) | 1.318953934 |
| regulation of spindle checkpoint (GO:0090231) | 1.318435163 |
| negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435) | 1.317355665 |
| negative regulation of DNA-templated transcription, elongation (GO:0032785) | 1.317299459 |
| peptidyl-arginine omega-N-methylation (GO:0035247) | 1.317230311 |
| base-excision repair, AP site formation (GO:0006285) | 1.312981391 |
| histone-serine phosphorylation (GO:0035404) | 1.312130664 |
| regulation of DNA endoreduplication (GO:0032875) | 1.311121339 |
| IMP metabolic process (GO:0046040) | 1.309379586 |
| DNA synthesis involved in DNA repair (GO:0000731) | 1.308282818 |
| regulation of translational fidelity (GO:0006450) | 1.308271029 |
| pseudouridine synthesis (GO:0001522) | 1.306686269 |
| macromolecular complex disassembly (GO:0032984) | 1.30544431 |
| centrosome organization (GO:0051297) | 1.303243587 |
| rRNA metabolic process (GO:0016072) | 1.299627865 |
| regulation of mitochondrial translation (GO:0070129) | 1.299476886 |
| transcription elongation from RNA polymerase III promoter (GO:0006385) | 1.296622321 |
| termination of RNA polymerase III transcription (GO:0006386) | 1.296622321 |
| proline biosynthetic process (GO:0006561) | 1.296549449 |
| ribosome biogenesis (GO:0042254) | 1.293040962 |
| regulation of transcription regulatory region DNA binding (GO:2000677) | 1.292021363 |
| 'de novo' posttranslational protein folding (GO:0051084) | 1.290554565 |
| ncRNA 3'-end processing (GO:0043628) | 1.290243456 |
| centriole replication (GO:0007099) | 1.28779747 |
| * G2/M transition of mitotic cell cycle (GO:0000086) | 1.287301473 |
| * cell cycle G2/M phase transition (GO:0044839) | 1.287301473 |
| DNA double-strand break processing (GO:0000729) | 1.286938769 |
| spindle assembly (GO:0051225) | 1.285916774 |
| recombinational repair (GO:0000725) | 1.285806109 |